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Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, NJ (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, MA (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, MA (C.K); Merck Research Laboratories, Department of Bioanalytics, Palo Alto, CA (W.S, G.A) This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on March 4, 2015 as DOI: 10.1124/dmd.114.061317